Structural and Functional Aspects of Class A Carbapenemases

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Structural and Functional Aspects of Class A Carbapenemases

The fight against infectious diseases is probably one of the greatest public health challenges faced by our society, especially with the emergence of carbapenem-resistant gram-negatives that are in some cases pan-drug resistant. Currently,β-lactamase-mediated resistance does not spare even the newest and most powerful β-lactams (carbapenems), whose activity is challenged by carbapenemases. The ...

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Class A carbapenemases.

Carbapenems, such as imipenem and meropenem, are most often used to treat infections caused by enterobacteria that produce extended-spectrum beta-lactamases, and the emergence of enzymes capable of inactivating carbapenems would therefore limit the options for treatment. Carbapenem resistance in Enterobacteriaceae is rare, but class A beta-lactamases with activity against the carbapenems are be...

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Water can be considered to be the reason for existence and the main factor in formation of some of the traditional Iranian architectural structures. Innovative technologies such as [water] mills and water reservoirs etc. can be placed in this category. These structures are the result of the interaction of the previous generations with nature and utilising its various elements. The human of the ...

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ژورنال

عنوان ژورنال: Current Drug Targets

سال: 2016

ISSN: 1389-4501

DOI: 10.2174/1389450117666160310144501